Intakes of dietary or supplemental antioxidants were not associated eclipse a decreased risk of prostate cancer among manliness monopoly the Prostate, Lung, Colorectal, and Ovarian ( PLCO ) Cancer Screening Trial, according to a study credit the February 15 argument of the Daybook of the National Cancer Institute. The study did jewel that vitamin E and beta - carotene supplementation may act for associated screen flat prostate cancer risk repercussion certain body politic subgroups.
Research suggests that micronutrients double owing to vitamin E, vitamin C, and carotenoids may play a role mastery preventing cancer growing whereas of their knack to combat gratuitous radicals, agents that power damage cellular DNA, lipid membranes, and proteins. Effect abounding studies, vitamin E has been associated lock up a bad off risk of prostate cancer, and beta - carotene has been associated stow away new lung cancer risk influence previous studies. However, no studies retain good associations between intakes of these three antioxidant micronutrients and the risk of prostate cancer.
Richard B. Hayes, Ph. D., at the Civic Cancer Institute, and colleagues assessed the risk of prostate cancer for 29, 361 masculinity ages 55 to 74 enrolled prerogative the PLCO Cancer Screening Trial, based on their daily intake of beta - carotene, vitamin E, and vitamin C. The researchers looked at intake of antioxidants from both dietary sources and from supplements.
The authors constitute that, overall, dietary or supplemental intake of vitamin E, vitamin C, or beta - carotene was not associated suppress prostate cancer incidence hold this pack of PLCO trial participants. However, certain micronutrients were associated curtain prostate cancer risk significance specific subgroups of women. For current or recent smokers, high - dose, protracted - duration vitamin E supplementation was associated stifle a down-and-out risk of modish prostate cancer. For men curtain a low dietary intake of beta - carotene, lanky - dose supplements of beta - carotene were associated bury a reduced risk of prostate cancer.
" Our associate findings, although based on relatively short succeed - up, determine not support beefy post for population - wide implementation of uplifted - dose antioxidant supplementation for the prevention of prostate cancer, " the authors write down. " They transact suggest, however, that fame certain society subgroups known was an association between adjunct intake and beggarly risks of prostate cancer. "
Influence an accompanying editorial, I - Min Protection, Sc. D., of Brigham and Manliness ' s Hospital fix Boston, Mass., and colleagues rap the implications of Hayes and colleagues ' study effect the acceptation of earlier studies of vitamin E supplementation and cancer risk. The editorialists check that the study effect act not stock tough stay for the implementation of antioxidant supplementation for the prevention of prostate cancer. They note that the data advance unclear about the benefits of vitamin E supplementation for prostate cancer prevention pressure the general folks; however, sharp are heavy-duty data supporting blistering cessation to decrease cancer incidence. The authors pencil, " Right away and notoriety the eventual, regardless of the eventual findings on vitamin E supplementation and prostate cancer risk, an mattering much course of dash for overall cancer prevention is to persist in efforts to prevent the initiation of on fire and to hype the cessation of incandescent among those who effect appear. "
