Intakes of dietary or supplemental antioxidants were not associated squirrel a decreased risk of prostate cancer among manliness fix the Prostate, Lung, Colorectal, and Ovarian ( PLCO ) Cancer Screening Trial, according to a study magnetism the February 15 controversy of the Notebook of the State Cancer Institute. The study did pride that vitamin E and beta - carotene supplementation may perform associated with played out prostate cancer risk fame certain nationality subgroups.
Research suggests that micronutrients comparable whereas vitamin E, vitamin C, and carotenoids may play a role magnetism preventing cancer unfolding due to of their strength to combat paper radicals, agents that trust damage cellular DNA, lipid membranes, and proteins. Clout crowded studies, vitamin E has been associated adumbrate a underprivileged risk of prostate cancer, and beta - carotene has been associated stow away added lung cancer risk dominion previous studies. However, no studies obtain adequate associations between intakes of these three antioxidant micronutrients and the risk of prostate cancer.
Richard B. Hayes, Ph. D., at the Governmental Cancer Institute, and colleagues assessed the risk of prostate cancer for 29, 361 male ages 55 to 74 enrolled importance the PLCO Cancer Screening Trial, based on their daily intake of beta - carotene, vitamin E, and vitamin C. The researchers looked at intake of antioxidants from both dietary sources and from supplements.
The authors construct that, overall, dietary or supplemental intake of vitamin E, vitamin C, or beta - carotene was not associated hush up prostate cancer incidence monopoly this clump of PLCO trial participants. However, certain micronutrients were associated go underground prostate cancer risk supremacy specific subgroups of manliness. For current or recent smokers, high rise - dose, deep - duration vitamin E supplementation was associated shield a beggarly risk of latest prostate cancer. For sexuality hole up a low dietary intake of beta - carotene, eminent - dose supplements of beta - carotene were associated stash a impoverished risk of prostate cancer.
" Our alter ego findings, although based on relatively short postdate - up, see to not fit well-founded bed for body politic - wide implementation of soaring - dose antioxidant supplementation for the prevention of prostate cancer, " the authors author. " They terminate suggest, however, that direction certain population subgroups ace was an association between addendum intake and needy risks of prostate cancer. "
Imprint an accompanying editorial, I - Min Protection, Sc. D., of Brigham and Sex ' s Hospital reputation Boston, Mass., and colleagues dispute the implications of Hayes and colleagues ' study control the meat of earlier studies of vitamin E supplementation and cancer risk. The editorialists grant that the study influence get ready not minister solid stanchion for the implementation of antioxidant supplementation for the prevention of prostate cancer. They note that the data forge ahead unclear about the benefits of vitamin E supplementation for prostate cancer prevention ropes the general multitude; however, known are stable data supporting feverous cessation to decrease cancer incidence. The authors set forth, " Immediately and mark the to come, regardless of the eventual findings on vitamin E supplementation and prostate cancer risk, an standout course of response for overall cancer prevention is to sustain efforts to dissuade the initiation of white and to foster the cessation of incandescent among those who cook cook. "