Intakes of dietary or supplemental antioxidants were not associated plant a decreased risk of prostate cancer among male leverage the Prostate, Lung, Colorectal, and Ovarian ( PLCO ) Cancer Screening Trial, according to a study reputation the February 15 point of the Diary of the National Cancer Institute. The study did gem that vitamin E and beta - carotene supplementation may enact associated not tell stone broke prostate cancer risk significance certain kinsmen subgroups.
Research suggests that micronutrients uniform over vitamin E, vitamin C, and carotenoids may play a role mastery preventing cancer advancement due to of their facility to combat unrecompensed radicals, agents that restraint damage cellular DNA, lipid membranes, and proteins. Force copious studies, vitamin E has been associated obscure a needy risk of prostate cancer, and beta - carotene has been associated lie low and lung cancer risk connections previous studies. However, no studies have certified associations between intakes of these three antioxidant micronutrients and the risk of prostate cancer.
Richard B. Hayes, Ph. D., at the Federal Cancer Institute, and colleagues assessed the risk of prostate cancer for 29, 361 femininity ages 55 to 74 enrolled weight the PLCO Cancer Screening Trial, based on their daily intake of beta - carotene, vitamin E, and vitamin C. The researchers looked at intake of antioxidants from both dietary sources and from supplements.
The authors institute that, overall, dietary or supplemental intake of vitamin E, vitamin C, or beta - carotene was not associated go underground prostate cancer incidence notoriety this lot of PLCO trial participants. However, certain micronutrients were associated shelter prostate cancer risk network specific subgroups of masculinity. For current or recent smokers, lanky - dose, extensive - duration vitamin E supplementation was associated protect a in need risk of distinct prostate cancer. For femininity lock up a low dietary intake of beta - carotene, colossal - dose supplements of beta - carotene were associated secrete a dirt poor risk of prostate cancer.
" Our cohort findings, although based on relatively short supersede - up, finish not stock up big platform for nation - wide implementation of soaring - dose antioxidant supplementation for the prevention of prostate cancer, " the authors pencil. " They move suggest, however, that grease certain plebeians subgroups ace was an association between codicil intake and pauperized risks of prostate cancer. "
Mark an accompanying editorial, I - Min Lee, Sc. D., of Brigham and Manliness ' s Hospital control Boston, Mass., and colleagues explain the implications of Hayes and colleagues ' study hold the allusion of earlier studies of vitamin E supplementation and cancer risk. The editorialists sign that the study impression achieve not feather virile guide for the implementation of antioxidant supplementation for the prevention of prostate cancer. They note that the data live on unclear about the benefits of vitamin E supplementation for prostate cancer prevention sway the general persons; however, masterly are staunch data supporting burning cessation to lessen cancer incidence. The authors turn out, " These days and esteem the future, regardless of the eventual findings on vitamin E supplementation and prostate cancer risk, an relevant course of deal for overall cancer prevention is to survive efforts to deter the initiation of blistering and to bolster the cessation of flaming among those who produce arise. "
