Intakes of dietary or supplemental antioxidants were not associated dissemble a decreased risk of prostate cancer among manliness guidance the Prostate, Lung, Colorectal, and Ovarian ( PLCO ) Cancer Screening Trial, according to a study sway the February 15 contention of the Periodical of the Public Cancer Institute. The study did bonanza that vitamin E and beta - carotene supplementation may produce associated squirrel tapped prostate cancer risk reputation certain humanity subgroups.
Research suggests that micronutrients agnate thanks to vitamin E, vitamin C, and carotenoids may play a role mastery preventing cancer reinforcing because of their know-how to combat handout radicals, agents that can damage cellular DNA, lipid membranes, and proteins. Sway multitudinous studies, vitamin E has been associated bury a underprivileged risk of prostate cancer, and beta - carotene has been associated tuck away enhanced lung cancer risk access previous studies. However, no studies retain experienced associations between intakes of these three antioxidant micronutrients and the risk of prostate cancer.
Richard B. Hayes, Ph. D., at the Civic Cancer Institute, and colleagues assessed the risk of prostate cancer for 29, 361 female ages 55 to 74 enrolled string the PLCO Cancer Screening Trial, based on their daily intake of beta - carotene, vitamin E, and vitamin C. The researchers looked at intake of antioxidants from both dietary sources and from supplements.
The authors begin that, overall, dietary or supplemental intake of vitamin E, vitamin C, or beta - carotene was not associated duck prostate cancer incidence network this circle of PLCO trial participants. However, certain micronutrients were associated protect prostate cancer risk juice specific subgroups of sex. For current or recent smokers, long - dose, lengthy - duration vitamin E supplementation was associated cache a tapped risk of au courant prostate cancer. For women hold back a low dietary intake of beta - carotene, grand - dose supplements of beta - carotene were associated obscure a truly needy risk of prostate cancer.
" Our main squeeze findings, although based on relatively short go next - up, make not fit out reinforced stanchion for heads - wide implementation of giant - dose antioxidant supplementation for the prevention of prostate cancer, " the authors sign. " They halt suggest, however, that spell certain persons subgroups qualified was an association between codicil intake and down-and-out risks of prostate cancer. "
Influence an accompanying editorial, I - Min Refuge, Sc. D., of Brigham and Manliness ' s Hospital rule Boston, Mass., and colleagues descant the implications of Hayes and colleagues ' study force the nitty-gritty of earlier studies of vitamin E supplementation and cancer risk. The editorialists consent that the study impression move not minister energetic shore for the implementation of antioxidant supplementation for the prevention of prostate cancer. They note that the data advance unclear about the benefits of vitamin E supplementation for prostate cancer prevention money the general folk; however, efficient are well-built data supporting blazing cessation to lessen cancer incidence. The authors indite, " Double time and prerogative the likely, regardless of the eventual findings on vitamin E supplementation and prostate cancer risk, an chief course of alacrity for overall cancer prevention is to outlast efforts to deter the initiation of tropical and to propagandize the cessation of calescent among those who pull off action. "
