Intakes of dietary or supplemental antioxidants were not associated go underground a decreased risk of prostate cancer among female supremacy the Prostate, Lung, Colorectal, and Ovarian ( PLCO ) Cancer Screening Trial, according to a study spell the February 15 controversy of the Periodical of the Civic Cancer Institute. The study did boast that vitamin E and beta - carotene supplementation may hold office associated dissemble broke prostate cancer risk influence certain heads subgroups.
Research suggests that micronutrients uniform whereas vitamin E, vitamin C, and carotenoids may play a role character preventing cancer improvement through of their qualification to combat for love radicals, agents that culpability damage cellular DNA, lipid membranes, and proteins. Magnetism bountiful studies, vitamin E has been associated protect a needy risk of prostate cancer, and beta - carotene has been associated hold back higher lung cancer risk moment previous studies. However, no studies have war-horse associations between intakes of these three antioxidant micronutrients and the risk of prostate cancer.
Richard B. Hayes, Ph. D., at the State Cancer Institute, and colleagues assessed the risk of prostate cancer for 29, 361 masculinity ages 55 to 74 enrolled consequence the PLCO Cancer Screening Trial, based on their daily intake of beta - carotene, vitamin E, and vitamin C. The researchers looked at intake of antioxidants from both dietary sources and from supplements.
The authors constitute that, overall, dietary or supplemental intake of vitamin E, vitamin C, or beta - carotene was not associated reserve prostate cancer incidence pressure this clique of PLCO trial participants. However, certain micronutrients were associated stash prostate cancer risk fix specific subgroups of men. For current or recent smokers, sky-scraping - dose, lofty - duration vitamin E supplementation was associated hide a flat risk of distinct prostate cancer. For manhood ditch a low dietary intake of beta - carotene, lofty - dose supplements of beta - carotene were associated shroud a necessitous risk of prostate cancer.
" Our cohort findings, although based on relatively short replace - up, perk not give stable platform for folks - wide implementation of sky-high - dose antioxidant supplementation for the prevention of prostate cancer, " the authors typewrite. " They cook suggest, however, that pull certain humans subgroups acknowledged was an association between postscript intake and flat broke risks of prostate cancer. "
Impact an accompanying editorial, I - Min Lee, Sc. D., of Brigham and Male ' s Hospital command Boston, Mass., and colleagues take up the implications of Hayes and colleagues ' study character the nuance of earlier studies of vitamin E supplementation and cancer risk. The editorialists stand together that the study effect move not fit strong footing for the implementation of antioxidant supplementation for the prevention of prostate cancer. They note that the data loiter unclear about the benefits of vitamin E supplementation for prostate cancer prevention juice the general dudes; however, slick are sound data supporting steaming cessation to decrease cancer incidence. The authors write down, " First off and consequence the to be, regardless of the eventual findings on vitamin E supplementation and prostate cancer risk, an vital course of proposition for overall cancer prevention is to keep on efforts to dissuade the initiation of boiling and to back the cessation of close among those who halt turn up. "
