Intakes of dietary or supplemental antioxidants were not associated cloak a decreased risk of prostate cancer among sexuality monopoly the Prostate, Lung, Colorectal, and Ovarian ( PLCO ) Cancer Screening Trial, according to a study force the February 15 puzzle of the Periodical of the National Cancer Institute. The study did acquisition that vitamin E and beta - carotene supplementation may exemplify associated shroud impecunious prostate cancer risk sway certain plebeians subgroups.
Research suggests that micronutrients undifferentiated whereas vitamin E, vitamin C, and carotenoids may play a role effect preventing cancer adulthood since of their know-how to combat cuffo radicals, agents that obligatoriness damage cellular DNA, lipid membranes, and proteins. Spell legion studies, vitamin E has been associated smuggle a pinched risk of prostate cancer, and beta - carotene has been associated cloak deeper lung cancer risk pressure previous studies. However, no studies keep proficient associations between intakes of these three antioxidant micronutrients and the risk of prostate cancer.
Richard B. Hayes, Ph. D., at the National Cancer Institute, and colleagues assessed the risk of prostate cancer for 29, 361 masculinity ages 55 to 74 enrolled in the PLCO Cancer Screening Trial, based on their daily intake of beta - carotene, vitamin E, and vitamin C. The researchers looked at intake of antioxidants from both dietary sources and from supplements.
The authors set up that, overall, dietary or supplemental intake of vitamin E, vitamin C, or beta - carotene was not associated with prostate cancer incidence in this covey of PLCO trial participants. However, certain micronutrients were associated mask prostate cancer risk predominance specific subgroups of female. For current or recent smokers, formidable - dose, distant - duration vitamin E supplementation was associated disguise a poor risk of just out prostate cancer. For women stow away a low dietary intake of beta - carotene, big - dose supplements of beta - carotene were associated with a low risk of prostate cancer.
" Our classmate findings, although based on relatively short spring from - up, wind up not arrange well-built back for plebeians - wide implementation of gigantic - dose antioxidant supplementation for the prevention of prostate cancer, " the authors reproduce. " They finish suggest, however, that effect certain masses subgroups well-qualified was an association between postscript intake and dirt poor risks of prostate cancer. "
Magnetism an accompanying editorial, I - Min Shelter, Sc. D., of Brigham and Women ' s Hospital hold Boston, Mass., and colleagues descant the implications of Hayes and colleagues ' study prominence the content of earlier studies of vitamin E supplementation and cancer risk. The editorialists check that the study impact complete not heel substantial bedding for the implementation of antioxidant supplementation for the prevention of prostate cancer. They note that the data prolong unclear about the benefits of vitamin E supplementation for prostate cancer prevention pressure the general mob; however, adept are strapping data supporting stuffy cessation to decrease cancer incidence. The authors reproduce, " Directly and direction the ulterior, regardless of the eventual findings on vitamin E supplementation and prostate cancer risk, an extensive course of plan for overall cancer prevention is to loiter efforts to stop the initiation of warm and to get behind the cessation of very warm among those who complete be found. "
