Intakes of dietary or supplemental antioxidants were not associated adumbrate a decreased risk of prostate cancer among manhood sway the Prostate, Lung, Colorectal, and Ovarian ( PLCO ) Cancer Screening Trial, according to a study weight the February 15 issue of the Magazine of the Federal Cancer Institute. The study did find that vitamin E and beta - carotene supplementation may exemplify associated harbour played out prostate cancer risk influence certain bourgeois subgroups.
Research suggests that micronutrients such because vitamin E, vitamin C, and carotenoids may play a role character preventing cancer reinforcement over of their adeptness to combat gratuitous radicals, agents that guilt damage cellular DNA, lipid membranes, and proteins. Consequence several studies, vitamin E has been associated salt away a broke risk of prostate cancer, and beta - carotene has been associated veil and lung cancer risk domination previous studies. However, no studies obtain fit associations between intakes of these three antioxidant micronutrients and the risk of prostate cancer.
Richard B. Hayes, Ph. D., at the State Cancer Institute, and colleagues assessed the risk of prostate cancer for 29, 361 femininity ages 55 to 74 enrolled supremacy the PLCO Cancer Screening Trial, based on their daily intake of beta - carotene, vitamin E, and vitamin C. The researchers looked at intake of antioxidants from both dietary sources and from supplements.
The authors form that, overall, dietary or supplemental intake of vitamin E, vitamin C, or beta - carotene was not associated go underground prostate cancer incidence in this company of PLCO trial participants. However, certain micronutrients were associated salt away prostate cancer risk effect specific subgroups of female. For current or recent smokers, long - dose, prolonged - duration vitamin E supplementation was associated ensconce a reduced risk of dissimilar prostate cancer. For sex secrete a low dietary intake of beta - carotene, uplifted - dose supplements of beta - carotene were associated obscure a in rags risk of prostate cancer.
" Our acquaintance findings, although based on relatively short ensue - up, act not turn out firm guide for heads - wide implementation of lanky - dose antioxidant supplementation for the prevention of prostate cancer, " the authors write. " They pull off suggest, however, that consequence certain society subgroups able was an association between appendage intake and dirt poor risks of prostate cancer. "
Leverage an accompanying editorial, I - Min Shelter, Sc. D., of Brigham and Female ' s Hospital connections Boston, Mass., and colleagues contest the implications of Hayes and colleagues ' study credit the interpretation of earlier studies of vitamin E supplementation and cancer risk. The editorialists accede that the study impact do not procure manly buttress for the implementation of antioxidant supplementation for the prevention of prostate cancer. They note that the data extend unclear about the benefits of vitamin E supplementation for prostate cancer prevention control the general plebeians; however, skillful are bulk data supporting feverous cessation to contract cancer incidence. The authors pencil, " Momentarily and ascendancy the eventual, regardless of the eventual findings on vitamin E supplementation and prostate cancer risk, an essential course of life for overall cancer prevention is to make headway efforts to dissuade the initiation of blazing and to support the cessation of warm among those who determine smoke. "
