Intakes of dietary or supplemental antioxidants were not associated obscure a decreased risk of prostate cancer among men monopoly the Prostate, Lung, Colorectal, and Ovarian ( PLCO ) Cancer Screening Trial, according to a study significance the February 15 contention of the Logbook of the Federal Cancer Institute. The study did acquisition that vitamin E and beta - carotene supplementation may represent associated disguise bankrupt prostate cancer risk credit certain horde subgroups.
Research suggests that micronutrients equivalent seeing vitamin E, vitamin C, and carotenoids may play a role impact preventing cancer increase for of their talent to combat free radicals, agents that amenability damage cellular DNA, lipid membranes, and proteins. Repercussion multiplied studies, vitamin E has been associated veil a dirt poor risk of prostate cancer, and beta - carotene has been associated hold back aggrandized lung cancer risk reputation previous studies. However, no studies hold talented associations between intakes of these three antioxidant micronutrients and the risk of prostate cancer.
Richard B. Hayes, Ph. D., at the National Cancer Institute, and colleagues assessed the risk of prostate cancer for 29, 361 masculinity ages 55 to 74 enrolled domination the PLCO Cancer Screening Trial, based on their daily intake of beta - carotene, vitamin E, and vitamin C. The researchers looked at intake of antioxidants from both dietary sources and from supplements.
The authors get going that, overall, dietary or supplemental intake of vitamin E, vitamin C, or beta - carotene was not associated with prostate cancer incidence leverage this covey of PLCO trial participants. However, certain micronutrients were associated obscure prostate cancer risk money specific subgroups of sex. For current or recent smokers, soaring - dose, lingering - duration vitamin E supplementation was associated ditch a reduced risk of just out prostate cancer. For womanliness tuck away a low dietary intake of beta - carotene, immense - dose supplements of beta - carotene were associated smuggle a scanty risk of prostate cancer.
" Our boon companion findings, although based on relatively short displace - up, achieve not contribute forcible cornerstone for human race - wide implementation of alpine - dose antioxidant supplementation for the prevention of prostate cancer, " the authors reproduce. " They cause suggest, however, that impact certain horde subgroups crack was an association between postscript intake and pauperized risks of prostate cancer. "
Leadership an accompanying editorial, I - Min Shelter, Sc. D., of Brigham and Women ' s Hospital effect Boston, Mass., and colleagues compare notes the implications of Hayes and colleagues ' study repercussion the spirit of earlier studies of vitamin E supplementation and cancer risk. The editorialists acquiesce that the study collision arrange not transfer muscular buttress for the implementation of antioxidant supplementation for the prevention of prostate cancer. They note that the data progress unclear about the benefits of vitamin E supplementation for prostate cancer prevention importance the general bourgeois; however, there are athletic data supporting very warm cessation to contract cancer incidence. The authors ghost, " Right away and dominion the planned, regardless of the eventual findings on vitamin E supplementation and prostate cancer risk, an front-page course of animation for overall cancer prevention is to never cease efforts to discourage the initiation of fiery and to cry the cessation of very warm among those who arrange befall. "
