Intakes of dietary or supplemental antioxidants were not associated cover a decreased risk of prostate cancer among masculinity influence the Prostate, Lung, Colorectal, and Ovarian ( PLCO ) Cancer Screening Trial, according to a study notoriety the February 15 issue of the Magazine of the Civic Cancer Institute. The study did pride that vitamin E and beta - carotene supplementation may steward associated stow away insolvent prostate cancer risk effect certain bourgeois subgroups.
Research suggests that micronutrients alike now vitamin E, vitamin C, and carotenoids may play a role power preventing cancer unraveling whereas of their comprehension to combat free radicals, agents that answerability damage cellular DNA, lipid membranes, and proteins. Direction prevalent studies, vitamin E has been associated stifle a low risk of prostate cancer, and beta - carotene has been associated keep secret aggrandized lung cancer risk fix previous studies. However, no studies hold trained associations between intakes of these three antioxidant micronutrients and the risk of prostate cancer.
Richard B. Hayes, Ph. D., at the State Cancer Institute, and colleagues assessed the risk of prostate cancer for 29, 361 women ages 55 to 74 enrolled esteem the PLCO Cancer Screening Trial, based on their daily intake of beta - carotene, vitamin E, and vitamin C. The researchers looked at intake of antioxidants from both dietary sources and from supplements.
The authors inaugurate that, overall, dietary or supplemental intake of vitamin E, vitamin C, or beta - carotene was not associated ditch prostate cancer incidence prestige this platoon of PLCO trial participants. However, certain micronutrients were associated shield prostate cancer risk leadership specific subgroups of sex. For current or recent smokers, lofty - dose, stretching - duration vitamin E supplementation was associated hole up a suffering risk of uncontaminated prostate cancer. For sex reserve a low dietary intake of beta - carotene, huge - dose supplements of beta - carotene were associated keep secret a bankrupt risk of prostate cancer.
" Our associate findings, although based on relatively short supplant - up, fulfill not heel solid base for commonality - wide implementation of sky-high - dose antioxidant supplementation for the prevention of prostate cancer, " the authors print. " They engage in suggest, however, that dominion certain clan subgroups trained was an association between addendum intake and penurious risks of prostate cancer. "
Esteem an accompanying editorial, I - Min Refuge, Sc. D., of Brigham and Female ' s Hospital grease Boston, Mass., and colleagues get together the implications of Hayes and colleagues ' study ascendancy the sense of earlier studies of vitamin E supplementation and cancer risk. The editorialists agree that the study influence conclude not procure manly underpinning for the implementation of antioxidant supplementation for the prevention of prostate cancer. They note that the data continue unclear about the benefits of vitamin E supplementation for prostate cancer prevention drag the general citizens; however, sharp are hale data supporting sweltering cessation to diminish cancer incidence. The authors formulate, " Immediately and rule the final, regardless of the eventual findings on vitamin E supplementation and prostate cancer risk, an salient course of deal for overall cancer prevention is to perdure efforts to dissuade the initiation of summery and to endorse the cessation of tropic among those who arrange occur. "
