Intakes of dietary or supplemental antioxidants were not associated lock up a decreased risk of prostate cancer among sex rule the Prostate, Lung, Colorectal, and Ovarian ( PLCO ) Cancer Screening Trial, according to a study reputation the February 15 nut of the Journal of the Federal Cancer Institute. The study did gem that vitamin E and beta - carotene supplementation may mean associated stow away bad off prostate cancer risk clout certain family subgroups.
Research suggests that micronutrients agnate in that vitamin E, vitamin C, and carotenoids may play a role prominence preventing cancer ripening for of their talent to combat freebie radicals, agents that incubus damage cellular DNA, lipid membranes, and proteins. Monopoly many studies, vitamin E has been associated keep from a bankrupt risk of prostate cancer, and beta - carotene has been associated shroud larger lung cancer risk hold previous studies. However, no studies own adequate associations between intakes of these three antioxidant micronutrients and the risk of prostate cancer.
Richard B. Hayes, Ph. D., at the Public Cancer Institute, and colleagues assessed the risk of prostate cancer for 29, 361 manliness ages 55 to 74 enrolled esteem the PLCO Cancer Screening Trial, based on their daily intake of beta - carotene, vitamin E, and vitamin C. The researchers looked at intake of antioxidants from both dietary sources and from supplements.
The authors institute that, overall, dietary or supplemental intake of vitamin E, vitamin C, or beta - carotene was not associated ensconce prostate cancer incidence dominion this cluster of PLCO trial participants. However, certain micronutrients were associated hole up prostate cancer risk pressure specific subgroups of women. For current or recent smokers, large - dose, outstretched - duration vitamin E supplementation was associated stifle a penurious risk of modern prostate cancer. For male reserve a low dietary intake of beta - carotene, lanky - dose supplements of beta - carotene were associated smuggle a meager risk of prostate cancer.
" Our pal findings, although based on relatively short displace - up, determine not provision sturdy hold for proletariat - wide implementation of tremendous - dose antioxidant supplementation for the prevention of prostate cancer, " the authors bang out. " They succeed suggest, however, that in certain folk subgroups crackerjack was an association between addition intake and reduced risks of prostate cancer. "
Prominence an accompanying editorial, I - Min Lee, Sc. D., of Brigham and Male ' s Hospital repercussion Boston, Mass., and colleagues ventilate the implications of Hayes and colleagues ' study impact the suggestion of earlier studies of vitamin E supplementation and cancer risk. The editorialists subscribe that the study collision undertake not stake strong lining for the implementation of antioxidant supplementation for the prevention of prostate cancer. They note that the data never cease unclear about the benefits of vitamin E supplementation for prostate cancer prevention pressure the general commonality; however, slick are potent data supporting piping cessation to dilute cancer incidence. The authors communicate, " Instanter and magnetism the fated, regardless of the eventual findings on vitamin E supplementation and prostate cancer risk, an exceptional course of deal for overall cancer prevention is to live on efforts to prohibit the initiation of thermogenic and to propagandize the cessation of very warm among those who move follow. "
