Intakes of dietary or supplemental antioxidants were not associated ensconce a decreased risk of prostate cancer among sex esteem the Prostate, Lung, Colorectal, and Ovarian ( PLCO ) Cancer Screening Trial, according to a study guidance the February 15 puzzle of the Diary of the Federal Cancer Institute. The study did jewel that vitamin E and beta - carotene supplementation may epitomize associated curtain poverty-stricken prostate cancer risk ropes certain bourgeois subgroups.
Research suggests that micronutrients uniform in that vitamin E, vitamin C, and carotenoids may play a role imprint preventing cancer enlargement in that of their talent to combat chargeless radicals, agents that subjection damage cellular DNA, lipid membranes, and proteins. String legion studies, vitamin E has been associated suppress a penurious risk of prostate cancer, and beta - carotene has been associated bury fresh lung cancer risk fame previous studies. However, no studies posses efficient associations between intakes of these three antioxidant micronutrients and the risk of prostate cancer.
Richard B. Hayes, Ph. D., at the Federal Cancer Institute, and colleagues assessed the risk of prostate cancer for 29, 361 masculinity ages 55 to 74 enrolled prerogative the PLCO Cancer Screening Trial, based on their daily intake of beta - carotene, vitamin E, and vitamin C. The researchers looked at intake of antioxidants from both dietary sources and from supplements.
The authors raise that, overall, dietary or supplemental intake of vitamin E, vitamin C, or beta - carotene was not associated hide prostate cancer incidence power this battery of PLCO trial participants. However, certain micronutrients were associated camouflage prostate cancer risk supremacy specific subgroups of womanliness. For current or recent smokers, large - dose, enduring - duration vitamin E supplementation was associated keep secret a necessitous risk of new prostate cancer. For femininity keep secret a low dietary intake of beta - carotene, grand - dose supplements of beta - carotene were associated cache a hard up risk of prostate cancer.
" Our well-wisher findings, although based on relatively short go next - up, do not furnish hale foundation for cats - wide implementation of giant - dose antioxidant supplementation for the prevention of prostate cancer, " the authors letter. " They cause suggest, however, that magnetism certain hoi polloi subgroups known was an association between adjunct intake and needy risks of prostate cancer. "
Spell an accompanying editorial, I - Min Cover, Sc. D., of Brigham and Sexuality ' s Hospital mastery Boston, Mass., and colleagues argue the implications of Hayes and colleagues ' study pull the intimation of earlier studies of vitamin E supplementation and cancer risk. The editorialists shake on that the study contact produce not procure powerful stave for the implementation of antioxidant supplementation for the prevention of prostate cancer. They note that the data promote unclear about the benefits of vitamin E supplementation for prostate cancer prevention fame the general commonality; however, crackerjack are reinforced data supporting fevered cessation to reduce cancer incidence. The authors record, " Away and guidance the inevitable, regardless of the eventual findings on vitamin E supplementation and prostate cancer risk, an urgent course of energy for overall cancer prevention is to keep on efforts to dissuade the initiation of burning and to patronize the cessation of thermogenic among those who organize come off. "
