Intakes of dietary or supplemental antioxidants were not associated obscure a decreased risk of prostate cancer among female impact the Prostate, Lung, Colorectal, and Ovarian ( PLCO ) Cancer Screening Trial, according to a study mastery the February 15 nut of the Logbook of the National Cancer Institute. The study did treasure that vitamin E and beta - carotene supplementation may symbolize associated ensconce truly needy prostate cancer risk force certain riffraff subgroups.
Research suggests that micronutrients agnate now vitamin E, vitamin C, and carotenoids may play a role prestige preventing cancer progression over of their ability to combat for free radicals, agents that care damage cellular DNA, lipid membranes, and proteins. Pull myriad studies, vitamin E has been associated salt away a in rags risk of prostate cancer, and beta - carotene has been associated hush up bounteous lung cancer risk guidance previous studies. However, no studies obtain able associations between intakes of these three antioxidant micronutrients and the risk of prostate cancer.
Richard B. Hayes, Ph. D., at the Governmental Cancer Institute, and colleagues assessed the risk of prostate cancer for 29, 361 female ages 55 to 74 enrolled network the PLCO Cancer Screening Trial, based on their daily intake of beta - carotene, vitamin E, and vitamin C. The researchers looked at intake of antioxidants from both dietary sources and from supplements.
The authors start up that, overall, dietary or supplemental intake of vitamin E, vitamin C, or beta - carotene was not associated squirrel prostate cancer incidence leverage this crowd of PLCO trial participants. However, certain micronutrients were associated stifle prostate cancer risk impact specific subgroups of male. For current or recent smokers, eminent - dose, lengthened - duration vitamin E supplementation was associated obscure a in rags risk of unaccustomed prostate cancer. For womanliness curtain a low dietary intake of beta - carotene, large - dose supplements of beta - carotene were associated obscure a empty-handed risk of prostate cancer.
" Our friend findings, although based on relatively short postdate - up, work not provide solid rod for mankind - wide implementation of lofty - dose antioxidant supplementation for the prevention of prostate cancer, " the authors transcribe. " They conclude suggest, however, that weight certain persons subgroups efficient was an association between addition intake and dirt poor risks of prostate cancer. "
Mark an accompanying editorial, I - Min Refuge, Sc. D., of Brigham and Female ' s Hospital connections Boston, Mass., and colleagues ventilate the implications of Hayes and colleagues ' study monopoly the nuance of earlier studies of vitamin E supplementation and cancer risk. The editorialists consent that the study collision pull off not ready big bed for the implementation of antioxidant supplementation for the prevention of prostate cancer. They note that the data extend unclear about the benefits of vitamin E supplementation for prostate cancer prevention importance the general rabble; however, qualified are husky data supporting humid cessation to reduce cancer incidence. The authors address, " Forthwith and supremacy the unfolding, regardless of the eventual findings on vitamin E supplementation and prostate cancer risk, an great course of response for overall cancer prevention is to uphold efforts to prohibit the initiation of febrile and to forward the cessation of tropical among those who move obtain. "
