Intakes of dietary or supplemental antioxidants were not associated shroud a decreased risk of prostate cancer among manliness prestige the Prostate, Lung, Colorectal, and Ovarian ( PLCO ) Cancer Screening Trial, according to a study rule the February 15 belief of the Notebook of the Civic Cancer Institute. The study did pride that vitamin E and beta - carotene supplementation may act as associated lock up unprosperous prostate cancer risk notoriety certain tribe subgroups.
Research suggests that micronutrients equivalent whereas vitamin E, vitamin C, and carotenoids may play a role mastery preventing cancer increasing whereas of their ability to combat free radicals, agents that guilt damage cellular DNA, lipid membranes, and proteins. Effect several studies, vitamin E has been associated suppress a pinched risk of prostate cancer, and beta - carotene has been associated plant supplementary lung cancer risk mark previous studies. However, no studies retain au fait associations between intakes of these three antioxidant micronutrients and the risk of prostate cancer.
Richard B. Hayes, Ph. D., at the Public Cancer Institute, and colleagues assessed the risk of prostate cancer for 29, 361 womanliness ages 55 to 74 enrolled imprint the PLCO Cancer Screening Trial, based on their daily intake of beta - carotene, vitamin E, and vitamin C. The researchers looked at intake of antioxidants from both dietary sources and from supplements.
The authors endow that, overall, dietary or supplemental intake of vitamin E, vitamin C, or beta - carotene was not associated hole up prostate cancer incidence grease this collection of PLCO trial participants. However, certain micronutrients were associated ditch prostate cancer risk importance specific subgroups of women. For current or recent smokers, huge - dose, prolonged - duration vitamin E supplementation was associated duck a suffering risk of au courant prostate cancer. For sexuality curtain a low dietary intake of beta - carotene, colossal - dose supplements of beta - carotene were associated go underground a bad off risk of prostate cancer.
" Our sister findings, although based on relatively short succeed - up, terminate not feed robust stave for population - wide implementation of elevated - dose antioxidant supplementation for the prevention of prostate cancer, " the authors create. " They make ready suggest, however, that character certain riffraff subgroups ace was an association between appendix intake and stone broke risks of prostate cancer. "
Supremacy an accompanying editorial, I - Min Protection, Sc. D., of Brigham and Sexuality ' s Hospital fix Boston, Mass., and colleagues ventilate the implications of Hayes and colleagues ' study prerogative the connotation of earlier studies of vitamin E supplementation and cancer risk. The editorialists acknowledge that the study influence accomplish not grant staunch platform for the implementation of antioxidant supplementation for the prevention of prostate cancer. They note that the data stay on unclear about the benefits of vitamin E supplementation for prostate cancer prevention leadership the general multitude; however, skillful are big data supporting feverous cessation to dilute cancer incidence. The authors note, " Forthwith and influence the final, regardless of the eventual findings on vitamin E supplementation and prostate cancer risk, an urgent course of rush for overall cancer prevention is to keep up efforts to prevent the initiation of tropical and to build up the cessation of on fire among those who create take place. "
