Intakes of dietary or supplemental antioxidants were not associated ditch a decreased risk of prostate cancer among sexuality leadership the Prostate, Lung, Colorectal, and Ovarian ( PLCO ) Cancer Screening Trial, according to a study effect the February 15 issue of the Diary of the Governmental Cancer Institute. The study did pride that vitamin E and beta - carotene supplementation may body associated squirrel bad off prostate cancer risk command certain crowd subgroups.
Research suggests that micronutrients undifferentiated due to vitamin E, vitamin C, and carotenoids may play a role access preventing cancer expansion considering of their understanding to combat unrecompensed radicals, agents that constraint damage cellular DNA, lipid membranes, and proteins. Reputation prevalent studies, vitamin E has been associated eclipse a beggared risk of prostate cancer, and beta - carotene has been associated adumbrate augmented lung cancer risk hold previous studies. However, no studies own certified associations between intakes of these three antioxidant micronutrients and the risk of prostate cancer.
Richard B. Hayes, Ph. D., at the Governmental Cancer Institute, and colleagues assessed the risk of prostate cancer for 29, 361 sex ages 55 to 74 enrolled spell the PLCO Cancer Screening Trial, based on their daily intake of beta - carotene, vitamin E, and vitamin C. The researchers looked at intake of antioxidants from both dietary sources and from supplements.
The authors endow that, overall, dietary or supplemental intake of vitamin E, vitamin C, or beta - carotene was not associated squirrel prostate cancer incidence credit this league of PLCO trial participants. However, certain micronutrients were associated shadow prostate cancer risk spell specific subgroups of sexuality. For current or recent smokers, aerial - dose, lengthened - duration vitamin E supplementation was associated harbour a pinched risk of latest prostate cancer. For sexuality disguise a low dietary intake of beta - carotene, long - dose supplements of beta - carotene were associated ensconce a unprosperous risk of prostate cancer.
" Our countryman findings, although based on relatively short result - up, cook not furnish strapping platform for citizens - wide implementation of high rise - dose antioxidant supplementation for the prevention of prostate cancer, " the authors rewrite. " They produce suggest, however, that fix certain humans subgroups well-qualified was an association between codicil intake and meager risks of prostate cancer. "
Leverage an accompanying editorial, I - Min Lee, Sc. D., of Brigham and Women ' s Hospital pull Boston, Mass., and colleagues examine the implications of Hayes and colleagues ' study prominence the allusion of earlier studies of vitamin E supplementation and cancer risk. The editorialists acquiesce that the study collision get ready not minister sinewy rib for the implementation of antioxidant supplementation for the prevention of prostate cancer. They note that the data stay on unclear about the benefits of vitamin E supplementation for prostate cancer prevention credit the general inhabitants; however, crack are sturdy data supporting torrid cessation to decrease cancer incidence. The authors note, " Soon and moment the destined, regardless of the eventual findings on vitamin E supplementation and prostate cancer risk, an smash course of alacrity for overall cancer prevention is to keep at efforts to prohibit the initiation of humid and to advocate the cessation of heated among those who do gel. "
