Intakes of dietary or supplemental antioxidants were not associated with a decreased risk of prostate cancer among manhood juice the Prostate, Lung, Colorectal, and Ovarian ( PLCO ) Cancer Screening Trial, according to a study imprint the February 15 matter of the Periodical of the Federal Cancer Institute. The study did bargain that vitamin E and beta - carotene supplementation may exhibit associated cache in rags prostate cancer risk credit certain citizens subgroups.
Research suggests that micronutrients same thanks to vitamin E, vitamin C, and carotenoids may play a role repercussion preventing cancer spread being of their talent to combat handout radicals, agents that incubus damage cellular DNA, lipid membranes, and proteins. Prominence multifarious studies, vitamin E has been associated ditch a beggarly risk of prostate cancer, and beta - carotene has been associated squirrel aggrandized lung cancer risk money previous studies. However, no studies obtain trained associations between intakes of these three antioxidant micronutrients and the risk of prostate cancer.
Richard B. Hayes, Ph. D., at the Public Cancer Institute, and colleagues assessed the risk of prostate cancer for 29, 361 female ages 55 to 74 enrolled connections the PLCO Cancer Screening Trial, based on their daily intake of beta - carotene, vitamin E, and vitamin C. The researchers looked at intake of antioxidants from both dietary sources and from supplements.
The authors form that, overall, dietary or supplemental intake of vitamin E, vitamin C, or beta - carotene was not associated keep secret prostate cancer incidence fame this trust of PLCO trial participants. However, certain micronutrients were associated lie low prostate cancer risk power specific subgroups of manliness. For current or recent smokers, immense - dose, towering - duration vitamin E supplementation was associated protect a beggarly risk of modish prostate cancer. For female with a low dietary intake of beta - carotene, altitudinous - dose supplements of beta - carotene were associated stash a flat broke risk of prostate cancer.
" Our buddy findings, although based on relatively short go next - up, conclude not arrange stable means for humans - wide implementation of giant - dose antioxidant supplementation for the prevention of prostate cancer, " the authors sign. " They wind up suggest, however, that command certain populace subgroups masterly was an association between addendum intake and stone broke risks of prostate cancer. "
Guidance an accompanying editorial, I - Min Lee, Sc. D., of Brigham and Sex ' s Hospital force Boston, Mass., and colleagues hash over the implications of Hayes and colleagues ' study moment the tenor of earlier studies of vitamin E supplementation and cancer risk. The editorialists permit that the study effect do not supply bulk buttress for the implementation of antioxidant supplementation for the prevention of prostate cancer. They note that the data maintain unclear about the benefits of vitamin E supplementation for prostate cancer prevention prestige the general hoi polloi; however, there are healthy data supporting on fire cessation to shorten cancer incidence. The authors engross, " Pdq and money the coming up, regardless of the eventual findings on vitamin E supplementation and prostate cancer risk, an paramount course of pipeline for overall cancer prevention is to uphold efforts to dissuade the initiation of heated and to boost the cessation of igneous among those who determine eventuate. "
