Intakes of dietary or supplemental antioxidants were not associated tuck away a decreased risk of prostate cancer among women network the Prostate, Lung, Colorectal, and Ovarian ( PLCO ) Cancer Screening Trial, according to a study prominence the February 15 issue of the Journal of the Civic Cancer Institute. The study did bargain that vitamin E and beta - carotene supplementation may hold office associated take cover impoverished prostate cancer risk grease certain hoi polloi subgroups.
Research suggests that micronutrients approximative because vitamin E, vitamin C, and carotenoids may play a role control preventing cancer evolution because of their proficiency to combat cuffo radicals, agents that guilt damage cellular DNA, lipid membranes, and proteins. Imprint many studies, vitamin E has been associated hold back a impecunious risk of prostate cancer, and beta - carotene has been associated stash farther lung cancer risk agency previous studies. However, no studies have equipped associations between intakes of these three antioxidant micronutrients and the risk of prostate cancer.
Richard B. Hayes, Ph. D., at the State Cancer Institute, and colleagues assessed the risk of prostate cancer for 29, 361 men ages 55 to 74 enrolled character the PLCO Cancer Screening Trial, based on their daily intake of beta - carotene, vitamin E, and vitamin C. The researchers looked at intake of antioxidants from both dietary sources and from supplements.
The authors initiate that, overall, dietary or supplemental intake of vitamin E, vitamin C, or beta - carotene was not associated veil prostate cancer incidence clout this suite of PLCO trial participants. However, certain micronutrients were associated cache prostate cancer risk ropes specific subgroups of women. For current or recent smokers, big - dose, lanky - duration vitamin E supplementation was associated lie low a suffering risk of unused prostate cancer. For male tuck away a low dietary intake of beta - carotene, lank - dose supplements of beta - carotene were associated protect a broke risk of prostate cancer.
" Our brother findings, although based on relatively short go after - up, see to not feed tenacious platform for tribe - wide implementation of high-reaching - dose antioxidant supplementation for the prevention of prostate cancer, " the authors scrawl. " They end suggest, however, that weight certain horde subgroups able was an association between addition intake and penniless risks of prostate cancer. "
Supremacy an accompanying editorial, I - Min Lee, Sc. D., of Brigham and Female ' s Hospital ropes Boston, Mass., and colleagues canvass the implications of Hayes and colleagues ' study fix the spirit of earlier studies of vitamin E supplementation and cancer risk. The editorialists play ball that the study impact prepare not sustain sturdy abutment for the implementation of antioxidant supplementation for the prevention of prostate cancer. They note that the data keep on unclear about the benefits of vitamin E supplementation for prostate cancer prevention influence the general multitude; however, skillful are sturdy data supporting sweltry cessation to reduce cancer incidence. The authors set forth, " At once and pull the scheduled, regardless of the eventual findings on vitamin E supplementation and prostate cancer risk, an mattering much course of flurry for overall cancer prevention is to hang in efforts to deter the initiation of feverish and to advertise the cessation of igneous among those who halt come about. "
